Drug interactions
Apalutamide + Sertraline
Severity: Moderate
Apalutamide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces several drug-metabolizing enzymes, including CYP2C19 and CYP3A4, which contribute to sertraline clearance. Sertraline exposure may fall and antidepressant effect may be lost.
What this interaction means in plain words
Apalutamide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Sertraline belongs to Central Nervous System.
Why it happens
Enzyme induction (CYP2C19, CYP3A4 and others) by apalutamide increases sertraline metabolism.
What to do
Monitor for relapse of depressive or anxiety symptoms after starting apalutamide. Titrate the sertraline dose to response or consider an alternative antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Sertraline?
MediHelp rates the interaction as moderate. Apalutamide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces several drug-metabolizing enzymes, including CYP2C19 and CYP3A4, which contribute to sertraline clearance. Sertraline exposure may fall and antidepressant effect may be lost.
How serious is the interaction between Apalutamide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for relapse of depressive or anxiety symptoms after starting apalutamide. Titrate the sertraline dose to response or consider an alternative antidepressant.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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