Drug interactions
Apalutamide + Sufentanil
Severity: Moderate
Apalutamide and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide can reduce sufentanil concentrations and analgesic effect. Inducer discontinuation may later cause a rise in opioid levels and respiratory depression.
What this interaction means in plain words
Apalutamide and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Sufentanil belongs to Musculoskeletal.
Why it happens
Apalutamide induces CYP3A4, increasing sufentanil metabolism.
What to do
Monitor analgesic response and titrate sufentanil as needed. After stopping apalutamide, watch for opioid toxicity and respiratory depression as induction wanes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Apalutamide with Sufentanil?
MediHelp rates the interaction as moderate. Apalutamide and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide can reduce sufentanil concentrations and analgesic effect. Inducer discontinuation may later cause a rise in opioid levels and respiratory depression.
How serious is the interaction between Apalutamide and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and titrate sufentanil as needed. After stopping apalutamide, watch for opioid toxicity and respiratory depression as induction wanes.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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