Drug interactions
Apalutamide + Sulphasalazine
Severity: Minor
Apalutamide and Sulphasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine is a substrate of the efflux transporter BCRP, and apalutamide weakly induces BCRP, which could lower sulfasalazine exposure. The clinical effect is probably small.
What this interaction means in plain words
Apalutamide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Apalutamide weakly induces BCRP, potentially lowering sulfasalazine absorption and increasing its elimination.
What to do
No dose change is generally needed; monitor for reduced response to sulfasalazine in inflammatory bowel disease or arthritis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Asciminib + Sulphasalazine Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Sulphasalazine?
MediHelp rates the interaction as minor. Apalutamide and Sulphasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine is a substrate of the efflux transporter BCRP, and apalutamide weakly induces BCRP, which could lower sulfasalazine exposure. The clinical effect is probably small.
How serious is the interaction between Apalutamide and Sulphasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for reduced response to sulfasalazine in inflammatory bowel disease or arthritis.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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