Drug interactions
Apalutamide + Umeclidinium-vilanterol
Severity: Moderate
Apalutamide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and may reduce vilanterol exposure, which could weaken bronchodilation. The effect is probably modest, since vilanterol also has a low systemic exposure.
What this interaction means in plain words
Apalutamide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
CYP3A4 induction increases vilanterol metabolism.
What to do
Monitor respiratory symptoms and lung function for loss of effect. Add or switch bronchodilator therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Apalutamide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and may reduce vilanterol exposure, which could weaken bronchodilation. The effect is probably modest, since vilanterol also has a low systemic exposure.
How serious is the interaction between Apalutamide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and lung function for loss of effect. Add or switch bronchodilator therapy if control worsens.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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