Drug interactions
Bazedoxifene-conjugated estrogens + Crofelemer
Severity: Minor
Bazedoxifene-conjugated estrogens and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 and transporters in the gut lumen, but it is minimally absorbed. A clinically meaningful increase in estrogen or bazedoxifene exposure is unlikely.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Possible local intestinal inhibition of CYP3A4 and transporters, with negligible systemic effect.
What to do
No dose adjustment is required. Monitor for estrogen-related adverse effects only if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Crofelemer?
MediHelp rates the interaction as minor. Bazedoxifene-conjugated estrogens and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 and transporters in the gut lumen, but it is minimally absorbed. A clinically meaningful increase in estrogen or bazedoxifene exposure is unlikely.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for estrogen-related adverse effects only if symptoms arise.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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