Drug interactions
Apixaban + Stiripentol
Severity: Moderate
Apixaban and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol can both inhibit and induce CYP3A4 and may inhibit P-gp, so apixaban exposure may change in either direction. This creates uncertainty in both bleeding and thrombosis risk.
What this interaction means in plain words
Apixaban and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 induction/inhibition and P-gp inhibition by stiripentol alter apixaban disposition.
What to do
Monitor for bleeding and thromboembolic events when stiripentol is started, changed or stopped. Consider an alternative anticoagulant if control is unstable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Apixaban with Stiripentol?
MediHelp rates the interaction as moderate. Apixaban and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol can both inhibit and induce CYP3A4 and may inhibit P-gp, so apixaban exposure may change in either direction. This creates uncertainty in both bleeding and thrombosis risk.
How serious is the interaction between Apixaban and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and thromboembolic events when stiripentol is started, changed or stopped. Consider an alternative anticoagulant if control is unstable.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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