Drug interactions
Apixaban + Vortioxetine
Severity: Moderate
Apixaban and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine is a serotonergic antidepressant that can modestly impair platelet function. Combined with apixaban this may increase bleeding risk, although the effect is probably smaller than with SSRIs.
What this interaction means in plain words
Apixaban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: reduced platelet serotonin uptake combined with factor Xa inhibition.
What to do
Monitor for bruising, GI bleeding and other bleeding signs, especially at treatment initiation. Counsel the patient to report bleeding promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Apixaban with Vortioxetine?
MediHelp rates the interaction as moderate. Apixaban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine is a serotonergic antidepressant that can modestly impair platelet function. Combined with apixaban this may increase bleeding risk, although the effect is probably smaller than with SSRIs.
How serious is the interaction between Apixaban and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, GI bleeding and other bleeding signs, especially at treatment initiation. Counsel the patient to report bleeding promptly.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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