Drug interactions
Apomorphine + Aripiprazole
Severity: Moderate
Apomorphine and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine is a dopamine agonist used in Parkinson's disease, whereas aripiprazole is a dopamine D2 partial agonist/antagonist. Aripiprazole can blunt the antiparkinsonian effect of apomorphine and may worsen motor symptoms.
What this interaction means in plain words
Apomorphine and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Aripiprazole belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Monitor motor control when the two are used together and consider a lower-risk antipsychotic such as quetiapine or clozapine if psychosis treatment is needed in Parkinson's disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Aripiprazole?
MediHelp rates the interaction as moderate. Apomorphine and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine is a dopamine agonist used in Parkinson's disease, whereas aripiprazole is a dopamine D2 partial agonist/antagonist. Aripiprazole can blunt the antiparkinsonian effect of apomorphine and may worsen motor symptoms.
How serious is the interaction between Apomorphine and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor control when the two are used together and consider a lower-risk antipsychotic such as quetiapine or clozapine if psychosis treatment is needed in Parkinson's disease.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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