Drug interactions
Apomorphine + Azelastine-fluticasone
Severity: Moderate
Apomorphine and Azelastine-fluticasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, so combined use may increase drowsiness, and apomorphine can cause sudden sleep onset. Nasal azelastine has limited systemic exposure, so the effect is generally modest.
What this interaction means in plain words
Apomorphine and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Azelastine-fluticasone belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for daytime sedation and sudden sleep episodes, and counsel on driving. Prefer a non-sedating alternative if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Azelastine-fluticasone?
MediHelp rates the interaction as moderate. Apomorphine and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, so combined use may increase drowsiness, and apomorphine can cause sudden sleep onset. Nasal azelastine has limited systemic exposure, so the effect is generally modest.
How serious is the interaction between Apomorphine and Azelastine-fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime sedation and sudden sleep episodes, and counsel on driving. Prefer a non-sedating alternative if drowsiness is troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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