Drug interactions
Apomorphine + Azithromycin
Severity: Moderate
Apomorphine and Azithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine has been associated with QT prolongation, and azithromycin can also prolong the QT interval. Used together they may increase the risk of ventricular arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Apomorphine and Azithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Azithromycin belongs to Anti Bacterial.
Why it happens
Additive QT interval prolongation.
What to do
Check a baseline ECG and electrolytes and monitor for palpitations or syncope. Choose a non-QT-prolonging antibiotic if the patient has additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Azithromycin?
MediHelp rates the interaction as moderate. Apomorphine and Azithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine has been associated with QT prolongation, and azithromycin can also prolong the QT interval. Used together they may increase the risk of ventricular arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Apomorphine and Azithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor for palpitations or syncope. Choose a non-QT-prolonging antibiotic if the patient has additional risk factors.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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