Drug interactions
Apomorphine + Baclofen
Severity: Moderate
Apomorphine and Baclofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and orthostatic hypotension, so combined use may increase sedation and falls. Apomorphine can also cause sudden sleep onset.
What this interaction means in plain words
Apomorphine and Baclofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Baclofen belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure and counsel the patient about falls and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Baclofen?
MediHelp rates the interaction as moderate. Apomorphine and Baclofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness and orthostatic hypotension, so combined use may increase sedation and falls. Apomorphine can also cause sudden sleep onset.
How serious is the interaction between Apomorphine and Baclofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure and counsel the patient about falls and driving.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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