Drug interactions
Apomorphine + Brompheniramine
Severity: Moderate
Apomorphine and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause drowsiness, sudden sleep onset and hypotension, and brompheniramine may add to sedation. Impaired alertness is the main concern.
What this interaction means in plain words
Apomorphine and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Brompheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from dopamine agonism and H1 antagonism.
What to do
Monitor for excessive somnolence and orthostatic symptoms, and advise caution with driving. Consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brompheniramine
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Brompheniramine?
MediHelp rates the interaction as moderate. Apomorphine and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause drowsiness, sudden sleep onset and hypotension, and brompheniramine may add to sedation. Impaired alertness is the main concern.
How serious is the interaction between Apomorphine and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive somnolence and orthostatic symptoms, and advise caution with driving. Consider a non-sedating antihistamine.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Brompheniramine page.
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