Drug interactions
Apomorphine + Cyclizine
Severity: Moderate
Apomorphine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can cause somnolence and sudden sleep onset, and cyclizine adds sedation. Cyclizine also has central anticholinergic and weak dopamine-blocking effects that may modestly oppose apomorphine in Parkinson disease.
What this interaction means in plain words
Apomorphine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive CNS depression, with possible weak antagonism of dopaminergic effect.
What to do
Monitor for excess sedation and worsening motor control. Domperidone is the usual antiemetic with apomorphine, so prefer it where available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Cyclizine?
MediHelp rates the interaction as moderate. Apomorphine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can cause somnolence and sudden sleep onset, and cyclizine adds sedation. Cyclizine also has central anticholinergic and weak dopamine-blocking effects that may modestly oppose apomorphine in Parkinson disease.
How serious is the interaction between Apomorphine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and worsening motor control. Domperidone is the usual antiemetic with apomorphine, so prefer it where available.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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