Drug interactions
Apomorphine + Fluticasone-vilanterol
Severity: Moderate
Apomorphine and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine has been associated with QT interval prolongation, and vilanterol, a long-acting beta2-agonist, can also affect cardiac repolarization and raise heart rate. Used together, they may add to the risk of ventricular arrhythmia, particularly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Apomorphine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta-adrenergic cardiovascular stimulation.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium before starting. Monitor for palpitations or syncope and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Apomorphine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine has been associated with QT interval prolongation, and vilanterol, a long-acting beta2-agonist, can also affect cardiac repolarization and raise heart rate. Used together, they may add to the risk of ventricular arrhythmia, particularly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Apomorphine and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium before starting. Monitor for palpitations or syncope and use the lowest effective doses.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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