Drug interactions
Apomorphine + Ipratropium-salbutamol
Severity: Moderate
Apomorphine and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salbutamol and apomorphine can prolong the QT interval or provoke tachyarrhythmias, especially at higher doses. Combined use may raise arrhythmia risk, particularly with hypokalemia or underlying heart disease.
What this interaction means in plain words
Apomorphine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta-2-mediated hypokalemia and tachycardia.
What to do
Check potassium and magnesium and consider an ECG in patients with cardiac risk factors. Avoid excessive salbutamol dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Apomorphine and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salbutamol and apomorphine can prolong the QT interval or provoke tachyarrhythmias, especially at higher doses. Combined use may raise arrhythmia risk, particularly with hypokalemia or underlying heart disease.
How serious is the interaction between Apomorphine and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and consider an ECG in patients with cardiac risk factors. Avoid excessive salbutamol dosing.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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