Drug interactions
Apomorphine + Orphenadrin
Severity: Moderate
Apomorphine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, and apomorphine may cause hypotension and sudden sleep onset. Orphenadrine's anticholinergic effects may also add to confusion or hallucinations in susceptible patients.
What this interaction means in plain words
Apomorphine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor for excessive sedation, confusion and orthostatic hypotension, and advise caution with driving. Reduce the dose of either drug if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Orphenadrin?
MediHelp rates the interaction as moderate. Apomorphine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, and apomorphine may cause hypotension and sudden sleep onset. Orphenadrine's anticholinergic effects may also add to confusion or hallucinations in susceptible patients.
How serious is the interaction between Apomorphine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, confusion and orthostatic hypotension, and advise caution with driving. Reduce the dose of either drug if adverse effects occur.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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