Drug interactions
Apomorphine + Pramipexole
Severity: Moderate
Apomorphine and Pramipexole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dopamine agonists, so combined use increases dopaminergic effects including nausea, orthostatic hypotension, somnolence, hallucinations and dyskinesia. Sudden sleep onset and impulse control disorders may also be more likely.
What this interaction means in plain words
Apomorphine and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Pramipexole belongs to Cardiovascular.
Why it happens
Additive dopamine receptor agonism.
What to do
Monitor blood pressure, sedation and psychiatric symptoms, and reduce the dose of one agent if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Pramipexole?
MediHelp rates the interaction as moderate. Apomorphine and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dopamine agonists, so combined use increases dopaminergic effects including nausea, orthostatic hypotension, somnolence, hallucinations and dyskinesia. Sudden sleep onset and impulse control disorders may also be more likely.
How serious is the interaction between Apomorphine and Pramipexole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, sedation and psychiatric symptoms, and reduce the dose of one agent if adverse effects occur.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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