Drug interactions
Apomorphine + Primaquine
Severity: Moderate
Apomorphine and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to QT interval prolongation, so using them together may increase the risk of torsades de pointes. The risk is higher with bradycardia, electrolyte disturbances or congenital long QT.
What this interaction means in plain words
Apomorphine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium. Avoid the combination in patients with congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Primaquine?
MediHelp rates the interaction as moderate. Apomorphine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been linked to QT interval prolongation, so using them together may increase the risk of torsades de pointes. The risk is higher with bradycardia, electrolyte disturbances or congenital long QT.
How serious is the interaction between Apomorphine and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, and correct potassium and magnesium. Avoid the combination in patients with congenital long QT syndrome.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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