Drug interactions
Apomorphine + Thioridazine
Severity: Contraindicated
Apomorphine and Thioridazine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and apomorphine also causes orthostatic hypotension. Together they raise the risk of torsades de pointes. Thioridazine also antagonizes the dopaminergic effect of apomorphine.
What this interaction means in plain words
Apomorphine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus D2 antagonism by thioridazine opposing apomorphine.
What to do
Avoid the combination. Use an antipsychotic with low QT risk and little D2 blockade in patients who need apomorphine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Thioridazine?
MediHelp rates the interaction as contraindicated. Apomorphine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and apomorphine also causes orthostatic hypotension. Together they raise the risk of torsades de pointes. Thioridazine also antagonizes the dopaminergic effect of apomorphine.
How serious is the interaction between Apomorphine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use an antipsychotic with low QT risk and little D2 blockade in patients who need apomorphine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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