Drug interactions
Apomorphine + Umeclidinium-vilanterol
Severity: Moderate
Apomorphine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine has been associated with QT prolongation and orthostatic hypotension. Vilanterol may add to cardiac repolarization effects and tachycardia.
What this interaction means in plain words
Apomorphine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Possible additive QT prolongation and cardiovascular effects.
What to do
Check baseline ECG in patients with cardiac risk factors and monitor heart rate and blood pressure. Maintain normal potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Apomorphine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine has been associated with QT prolongation and orthostatic hypotension. Vilanterol may add to cardiac repolarization effects and tachycardia.
How serious is the interaction between Apomorphine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG in patients with cardiac risk factors and monitor heart rate and blood pressure. Maintain normal potassium and magnesium.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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