Drug interactions
Apomorphine + Ziprasidone
Severity: Major
Apomorphine and Ziprasidone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone blocks dopamine receptors and can counteract the effect of apomorphine, while both drugs can prolong the QT interval. This may reduce control of parkinsonian symptoms and increase arrhythmia risk.
What this interaction means in plain words
Apomorphine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apomorphine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Dopamine receptor antagonism opposing apomorphine agonism, plus additive QTc prolongation.
What to do
Avoid the combination; for psychosis in Parkinson disease use an agent with little dopamine blockade, and monitor ECG if concurrent use is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Ziprasidone?
MediHelp rates the interaction as major. Apomorphine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone blocks dopamine receptors and can counteract the effect of apomorphine, while both drugs can prolong the QT interval. This may reduce control of parkinsonian symptoms and increase arrhythmia risk.
How serious is the interaction between Apomorphine and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; for psychosis in Parkinson disease use an agent with little dopamine blockade, and monitor ECG if concurrent use is unavoidable.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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