Drug interactions
Aprepitant + Aripiprazole
Severity: Moderate
Aprepitant and Aripiprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole is cleared by CYP3A4 and CYP2D6, and aprepitant inhibits CYP3A4 moderately. Aripiprazole exposure may increase, leading to more sedation, akathisia or orthostatic effects.
What this interaction means in plain words
Aprepitant and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Aripiprazole belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4-mediated metabolism of aripiprazole.
What to do
Monitor for adverse effects of aripiprazole during and shortly after aprepitant courses. Reduce the aripiprazole dose if effects emerge, particularly in CYP2D6 poor metabolizers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aprepitant with Aripiprazole?
MediHelp rates the interaction as moderate. Aprepitant and Aripiprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aripiprazole is cleared by CYP3A4 and CYP2D6, and aprepitant inhibits CYP3A4 moderately. Aripiprazole exposure may increase, leading to more sedation, akathisia or orthostatic effects.
How serious is the interaction between Aprepitant and Aripiprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of aripiprazole during and shortly after aprepitant courses. Reduce the aripiprazole dose if effects emerge, particularly in CYP2D6 poor metabolizers.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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