Drug interactions
Aprepitant + Buspirone
Severity: Moderate
Aprepitant and Buspirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buspirone undergoes extensive first-pass CYP3A4 metabolism, so CYP3A4 inhibitors can raise its levels substantially. Aprepitant, a moderate inhibitor, may increase buspirone exposure, leading to dizziness, drowsiness, nausea and headache.
What this interaction means in plain words
Aprepitant and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Buspirone belongs to Central Nervous System.
Why it happens
Aprepitant inhibits intestinal and hepatic CYP3A4, reducing buspirone first-pass metabolism.
What to do
Monitor for buspirone adverse effects and consider a lower buspirone dose while aprepitant is given.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Aprepitant with Buspirone?
MediHelp rates the interaction as moderate. Aprepitant and Buspirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buspirone undergoes extensive first-pass CYP3A4 metabolism, so CYP3A4 inhibitors can raise its levels substantially. Aprepitant, a moderate inhibitor, may increase buspirone exposure, leading to dizziness, drowsiness, nausea and headache.
How serious is the interaction between Aprepitant and Buspirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for buspirone adverse effects and consider a lower buspirone dose while aprepitant is given.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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