Drug interactions
Aprepitant + Cabazitaxel
Severity: Moderate
Aprepitant and Cabazitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabazitaxel is metabolized mainly by CYP3A4. Moderate inhibition by aprepitant may raise cabazitaxel exposure and increase the risk of neutropenia and other toxicities.
What this interaction means in plain words
Aprepitant and Cabazitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Cabazitaxel belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, decreasing cabazitaxel clearance.
What to do
Monitor blood counts closely and watch for signs of infection and gastrointestinal toxicity. Reduce the cabazitaxel dose or delay treatment if severe toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aprepitant and Cabazitaxel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Aprepitant with Cabazitaxel?
MediHelp rates the interaction as moderate. Aprepitant and Cabazitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabazitaxel is metabolized mainly by CYP3A4. Moderate inhibition by aprepitant may raise cabazitaxel exposure and increase the risk of neutropenia and other toxicities.
How serious is the interaction between Aprepitant and Cabazitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and watch for signs of infection and gastrointestinal toxicity. Reduce the cabazitaxel dose or delay treatment if severe toxicity occurs.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
