Drug interactions
Aprepitant + Capivasertib
Severity: Moderate
Aprepitant and Capivasertib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, a moderate CYP3A4 inhibitor, may increase capivasertib exposure. This may worsen toxicities such as hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Aprepitant and Capivasertib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Capivasertib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated capivasertib metabolism by aprepitant.
What to do
Reduce the capivasertib dose in line with its labeling when used with a moderate CYP3A inhibitor. Monitor blood glucose and for diarrhea and skin reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Capivasertib
Frequently asked questions
Can I take Aprepitant with Capivasertib?
MediHelp rates the interaction as moderate. Aprepitant and Capivasertib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant, a moderate CYP3A4 inhibitor, may increase capivasertib exposure. This may worsen toxicities such as hyperglycemia, diarrhea and rash.
How serious is the interaction between Aprepitant and Capivasertib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the capivasertib dose in line with its labeling when used with a moderate CYP3A inhibitor. Monitor blood glucose and for diarrhea and skin reactions.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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