Drug interactions
Aprepitant + Cilostazol
Severity: Moderate
Aprepitant and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol is metabolized by CYP3A4 and CYP2C19. Aprepitant may modestly increase cilostazol exposure, raising the risk of headache, palpitations, tachycardia and diarrhea.
What this interaction means in plain words
Aprepitant and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Cilostazol belongs to Cardiovascular.
Why it happens
Aprepitant inhibits CYP3A4, reducing cilostazol clearance.
What to do
Monitor for cilostazol adverse effects. Consider lowering the cilostazol dose if the patient has symptoms or other CYP inhibitors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Aprepitant with Cilostazol?
MediHelp rates the interaction as moderate. Aprepitant and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol is metabolized by CYP3A4 and CYP2C19. Aprepitant may modestly increase cilostazol exposure, raising the risk of headache, palpitations, tachycardia and diarrhea.
How serious is the interaction between Aprepitant and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cilostazol adverse effects. Consider lowering the cilostazol dose if the patient has symptoms or other CYP inhibitors are present.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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