Drug interactions
Aprepitant + Clopidogrel
Severity: Minor
Aprepitant and Clopidogrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clopidogrel is a prodrug partly activated by CYP3A4, so inhibiting this enzyme could reduce formation of the active metabolite. The clinical effect on platelet inhibition with aprepitant is uncertain and likely small, because CYP2C19 is the main activating enzyme.
What this interaction means in plain words
Aprepitant and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Clopidogrel belongs to Cardiovascular.
Why it happens
Aprepitant inhibits CYP3A4, a contributing pathway for clopidogrel bioactivation.
What to do
No dose adjustment is needed. In high-risk patients such as those with recent stent placement, be aware of possible reduced antiplatelet effect during aprepitant therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Clopidogrel
Frequently asked questions
Can I take Aprepitant with Clopidogrel?
MediHelp rates the interaction as minor. Aprepitant and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clopidogrel is a prodrug partly activated by CYP3A4, so inhibiting this enzyme could reduce formation of the active metabolite. The clinical effect on platelet inhibition with aprepitant is uncertain and likely small, because CYP2C19 is the main activating enzyme.
How serious is the interaction between Aprepitant and Clopidogrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. In high-risk patients such as those with recent stent placement, be aware of possible reduced antiplatelet effect during aprepitant therapy.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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