Drug interactions
Aprepitant + Dutasteride-tamsulosin
Severity: Moderate
Aprepitant and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to tamsulosin, which is partly cleared by CYP3A4. Higher tamsulosin levels may cause more dizziness, orthostatic hypotension and syncope. Dutasteride is also a CYP3A4 substrate, though the effect is less important clinically.
What this interaction means in plain words
Aprepitant and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4, reducing the metabolism of tamsulosin and dutasteride.
What to do
Monitor for orthostatic hypotension and dizziness, especially during the short aprepitant course. Advise patients to rise slowly and reduce the tamsulosin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Aprepitant and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to tamsulosin, which is partly cleared by CYP3A4. Higher tamsulosin levels may cause more dizziness, orthostatic hypotension and syncope. Dutasteride is also a CYP3A4 substrate, though the effect is less important clinically.
How serious is the interaction between Aprepitant and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness, especially during the short aprepitant course. Advise patients to rise slowly and reduce the tamsulosin dose if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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