Drug interactions
Aprepitant + Felodipine
Severity: Moderate
Aprepitant and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine is highly dependent on CYP3A4 for first-pass metabolism, so aprepitant may increase its levels. This can cause hypotension, flushing, headache and peripheral edema.
What this interaction means in plain words
Aprepitant and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Felodipine belongs to Cardiovascular.
Why it happens
Aprepitant inhibits intestinal and hepatic CYP3A4 metabolism of felodipine.
What to do
Monitor blood pressure and heart rate during the aprepitant course, and reduce the felodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Aprepitant with Felodipine?
MediHelp rates the interaction as moderate. Aprepitant and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine is highly dependent on CYP3A4 for first-pass metabolism, so aprepitant may increase its levels. This can cause hypotension, flushing, headache and peripheral edema.
How serious is the interaction between Aprepitant and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during the aprepitant course, and reduce the felodipine dose if hypotension or edema develops.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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