Drug interactions
Aprepitant + Imatinib
Severity: Moderate
Aprepitant and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is mainly metabolised by CYP3A4, so aprepitant may increase imatinib exposure. Higher levels could increase fluid retention, myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Aprepitant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Imatinib belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing imatinib clearance.
What to do
Monitor blood counts and signs of imatinib toxicity during aprepitant use; consider dose reduction if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Aprepitant with Imatinib?
MediHelp rates the interaction as moderate. Aprepitant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is mainly metabolised by CYP3A4, so aprepitant may increase imatinib exposure. Higher levels could increase fluid retention, myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Aprepitant and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of imatinib toxicity during aprepitant use; consider dose reduction if adverse effects emerge.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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