Drug interactions
Aprepitant + Isavuconazonium
Severity: Minor
Aprepitant and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate and moderate inhibitor; aprepitant is a substrate and moderate inducer/inhibitor. The combined effect on isavuconazole is uncertain, and a decrease in antifungal exposure is theoretically possible with repeated aprepitant dosing.
What this interaction means in plain words
Aprepitant and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Isavuconazonium belongs to Anti Fungals.
Why it happens
Aprepitant has mixed CYP3A4 inhibitory and inductive effects; the net effect on isavuconazole is not established.
What to do
No empiric adjustment is needed. Monitor clinical response to antifungal therapy and aprepitant tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Aprepitant with Isavuconazonium?
MediHelp rates the interaction as minor. Aprepitant and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a CYP3A4 substrate and moderate inhibitor; aprepitant is a substrate and moderate inducer/inhibitor. The combined effect on isavuconazole is uncertain, and a decrease in antifungal exposure is theoretically possible with repeated aprepitant dosing.
How serious is the interaction between Aprepitant and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric adjustment is needed. Monitor clinical response to antifungal therapy and aprepitant tolerability.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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