Drug interactions
Aprepitant + Naloxegol
Severity: Moderate
Aprepitant and Naloxegol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant can increase naloxegol exposure by inhibiting CYP3A4. This may cause opioid withdrawal symptoms and gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Aprepitant and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, reducing naloxegol metabolism.
What to do
If unavoidable, reduce naloxegol to 12.5 mg once daily and monitor for withdrawal symptoms and abdominal pain. Stop naloxegol if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Aprepitant with Naloxegol?
MediHelp rates the interaction as moderate. Aprepitant and Naloxegol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant can increase naloxegol exposure by inhibiting CYP3A4. This may cause opioid withdrawal symptoms and gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Aprepitant and Naloxegol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, reduce naloxegol to 12.5 mg once daily and monitor for withdrawal symptoms and abdominal pain. Stop naloxegol if adverse effects occur.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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