Drug interactions
Aprepitant + Nimodipine
Severity: Moderate
Aprepitant and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nimodipine is extensively metabolised by CYP3A4, so aprepitant may raise its concentrations. This may cause greater hypotension, which matters in patients with subarachnoid hemorrhage.
What this interaction means in plain words
Aprepitant and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Nimodipine belongs to Cardiovascular.
Why it happens
Aprepitant inhibits CYP3A4, decreasing first-pass and systemic metabolism of nimodipine.
What to do
Monitor blood pressure closely and consider splitting nimodipine doses or reducing the dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Aprepitant with Nimodipine?
MediHelp rates the interaction as moderate. Aprepitant and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nimodipine is extensively metabolised by CYP3A4, so aprepitant may raise its concentrations. This may cause greater hypotension, which matters in patients with subarachnoid hemorrhage.
How serious is the interaction between Aprepitant and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and consider splitting nimodipine doses or reducing the dose if hypotension develops.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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