Drug interactions
Aprepitant + Oliceridine
Severity: Moderate
Aprepitant and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is cleared mainly by CYP3A4 and CYP2D6, so aprepitant, as a moderate CYP3A4 inhibitor, is expected to increase oliceridine exposure. This raises the risk of excessive sedation and respiratory depression, and stopping aprepitant later may lower opioid effect.
What this interaction means in plain words
Aprepitant and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Oliceridine belongs to Musculoskeletal.
Why it happens
Aprepitant inhibits CYP3A4, decreasing oliceridine clearance and raising its plasma concentrations.
What to do
Monitor for sedation and respiratory depression and titrate oliceridine doses to effect, using less frequent dosing if needed. Reassess analgesia and watch for withdrawal if aprepitant is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aprepitant and Oliceridine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Aprepitant with Oliceridine?
MediHelp rates the interaction as moderate. Aprepitant and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is cleared mainly by CYP3A4 and CYP2D6, so aprepitant, as a moderate CYP3A4 inhibitor, is expected to increase oliceridine exposure. This raises the risk of excessive sedation and respiratory depression, and stopping aprepitant later may lower opioid effect.
How serious is the interaction between Aprepitant and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and titrate oliceridine doses to effect, using less frequent dosing if needed. Reassess analgesia and watch for withdrawal if aprepitant is discontinued.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
