Drug interactions
Aprepitant + Prednisone
Severity: Minor
Aprepitant and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to some corticosteroids, notably dexamethasone and methylprednisolone. Prednisone is mainly converted to prednisolone, and the effect is expected to be modest, though increased steroid effects are possible.
What this interaction means in plain words
Aprepitant and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Prednisone belongs to Endocrine.
Why it happens
Aprepitant inhibition of CYP3A4 may modestly reduce corticosteroid clearance.
What to do
Monitor for corticosteroid adverse effects during aprepitant courses; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Prednisone?
MediHelp rates the interaction as minor. Aprepitant and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant is a moderate CYP3A4 inhibitor and can raise exposure to some corticosteroids, notably dexamethasone and methylprednisolone. Prednisone is mainly converted to prednisolone, and the effect is expected to be modest, though increased steroid effects are possible.
How serious is the interaction between Aprepitant and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects during aprepitant courses; no routine dose change is needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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