Drug interactions
Aprepitant + Propafenone
Severity: Moderate
Aprepitant and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is metabolised by CYP2D6, CYP3A4 and CYP1A2, so aprepitant may increase its levels, especially in CYP2D6 poor metabolisers. Higher exposure could raise the risk of proarrhythmia, conduction delay and CNS effects.
What this interaction means in plain words
Aprepitant and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Propafenone belongs to Cardiovascular.
Why it happens
Aprepitant inhibits CYP3A4, reducing propafenone clearance.
What to do
Monitor ECG (PR and QRS intervals) and heart rate during aprepitant use, and lower the propafenone dose if conduction abnormalities occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Aprepitant with Propafenone?
MediHelp rates the interaction as moderate. Aprepitant and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone is metabolised by CYP2D6, CYP3A4 and CYP1A2, so aprepitant may increase its levels, especially in CYP2D6 poor metabolisers. Higher exposure could raise the risk of proarrhythmia, conduction delay and CNS effects.
How serious is the interaction between Aprepitant and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (PR and QRS intervals) and heart rate during aprepitant use, and lower the propafenone dose if conduction abnormalities occur.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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