Drug interactions
Aprepitant + Quetiapine
Severity: Moderate
Aprepitant and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is mainly cleared by CYP3A4, so aprepitant may increase its levels. This could cause greater sedation, orthostatic hypotension and QT prolongation.
What this interaction means in plain words
Aprepitant and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of quetiapine.
What to do
Monitor sedation and blood pressure and consider lowering quetiapine dose if effects are excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Aprepitant with Quetiapine?
MediHelp rates the interaction as moderate. Aprepitant and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is mainly cleared by CYP3A4, so aprepitant may increase its levels. This could cause greater sedation, orthostatic hypotension and QT prolongation.
How serious is the interaction between Aprepitant and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure and consider lowering quetiapine dose if effects are excessive.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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