Drug interactions
Aprepitant + Rifapentine
Severity: Moderate
Aprepitant and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and is expected to markedly reduce aprepitant exposure, as seen with rifampin. This may lead to inadequate control of chemotherapy-induced nausea and vomiting.
What this interaction means in plain words
Aprepitant and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 (and other enzymes), increasing aprepitant clearance.
What to do
Avoid the combination if possible; otherwise monitor antiemetic efficacy and add alternative antiemetic classes such as 5-HT3 antagonists or dexamethasone adjusted appropriately.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Aprepitant with Rifapentine?
MediHelp rates the interaction as moderate. Aprepitant and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and is expected to markedly reduce aprepitant exposure, as seen with rifampin. This may lead to inadequate control of chemotherapy-induced nausea and vomiting.
How serious is the interaction between Aprepitant and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor antiemetic efficacy and add alternative antiemetic classes such as 5-HT3 antagonists or dexamethasone adjusted appropriately.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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