Drug interactions
Aprepitant + Sufentanil
Severity: Moderate
Aprepitant and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared mainly by CYP3A4, and aprepitant may reduce its clearance. Prolonged sedation and respiratory depression are possible.
What this interaction means in plain words
Aprepitant and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Sufentanil belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 by aprepitant decreases sufentanil metabolism.
What to do
Monitor respiratory rate and sedation, and titrate sufentanil to effect with the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Aprepitant with Sufentanil?
MediHelp rates the interaction as moderate. Aprepitant and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is cleared mainly by CYP3A4, and aprepitant may reduce its clearance. Prolonged sedation and respiratory depression are possible.
How serious is the interaction between Aprepitant and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation, and titrate sufentanil to effect with the lowest effective dose.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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