Drug interactions
Aprepitant + Tamsulosin
Severity: Moderate
Aprepitant and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and can raise tamsulosin exposure, since tamsulosin is cleared partly by CYP3A4. Higher levels may increase hypotension, dizziness and orthostatic symptoms, especially with a multi-day aprepitant course.
What this interaction means in plain words
Aprepitant and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Tamsulosin belongs to Genitourinary.
Why it happens
Aprepitant inhibits CYP3A4-mediated metabolism of tamsulosin, reducing its clearance.
What to do
Monitor blood pressure and orthostatic symptoms during and shortly after the aprepitant course. Advise patients to rise slowly and reduce tamsulosin if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Aprepitant with Tamsulosin?
MediHelp rates the interaction as moderate. Aprepitant and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and can raise tamsulosin exposure, since tamsulosin is cleared partly by CYP3A4. Higher levels may increase hypotension, dizziness and orthostatic symptoms, especially with a multi-day aprepitant course.
How serious is the interaction between Aprepitant and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during and shortly after the aprepitant course. Advise patients to rise slowly and reduce tamsulosin if symptomatic hypotension develops.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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