Drug interactions
Aprepitant + Tinidazole
Severity: Minor
Aprepitant and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tinidazole is partly metabolized by CYP3A4, and aprepitant is a moderate inhibitor of that enzyme, though it also has a mild inducing effect on some pathways. The legacy direction of a decrease is not well supported, and no clinically meaningful change in tinidazole exposure is established.
What this interaction means in plain words
Aprepitant and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Tinidazole belongs to Anti Parasitic.
Why it happens
Aprepitant's CYP3A4 effects might alter tinidazole metabolism, but the direction and size of any change are not established.
What to do
No dose change is needed; monitor for tinidazole efficacy or adverse effects only if the course is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Aprepitant with Tinidazole?
MediHelp rates the interaction as minor. Aprepitant and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tinidazole is partly metabolized by CYP3A4, and aprepitant is a moderate inhibitor of that enzyme, though it also has a mild inducing effect on some pathways. The legacy direction of a decrease is not well supported, and no clinically meaningful change in tinidazole exposure is established.
How serious is the interaction between Aprepitant and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for tinidazole efficacy or adverse effects only if the course is prolonged.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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