Drug interactions
Aprepitant + Vinblastine
Severity: Moderate
Aprepitant and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and vinblastine is cleared mainly by CYP3A4. Exposure to vinblastine may rise, which could increase neutropenia and neurotoxicity. The size of the effect for short antiemetic courses is uncertain.
What this interaction means in plain words
Aprepitant and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Vinblastine belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing the hepatic and intestinal metabolism of vinblastine.
What to do
Monitor blood counts and watch for neuropathy, constipation or ileus during the chemotherapy cycle. Reduce the vinblastine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Vinblastine
Frequently asked questions
Can I take Aprepitant with Vinblastine?
MediHelp rates the interaction as moderate. Aprepitant and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and vinblastine is cleared mainly by CYP3A4. Exposure to vinblastine may rise, which could increase neutropenia and neurotoxicity. The size of the effect for short antiemetic courses is uncertain.
How serious is the interaction between Aprepitant and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for neuropathy, constipation or ileus during the chemotherapy cycle. Reduce the vinblastine dose if toxicity develops.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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