Drug interactions
Aprepitant + Zafirlukast
Severity: Minor
Aprepitant and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast is a weak CYP3A4 inhibitor in vitro, so a clinically meaningful rise in aprepitant levels is not established. Any effect would be small and unlikely to matter.
What this interaction means in plain words
Aprepitant and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Zafirlukast belongs to Respiratory.
Why it happens
Weak, mainly in vitro inhibition of CYP3A4 by zafirlukast could slightly reduce aprepitant clearance.
What to do
No dose change is needed. Be aware of possible increases in aprepitant adverse effects such as fatigue or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Zafirlukast?
MediHelp rates the interaction as minor. Aprepitant and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast is a weak CYP3A4 inhibitor in vitro, so a clinically meaningful rise in aprepitant levels is not established. Any effect would be small and unlikely to matter.
How serious is the interaction between Aprepitant and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Be aware of possible increases in aprepitant adverse effects such as fatigue or dizziness.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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