Drug interactions
Argatroban + Vortioxetine
Severity: Moderate
Argatroban and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Argatroban is a direct thrombin inhibitor, and vortioxetine may impair platelet function through reduced platelet serotonin uptake. The combination may increase bleeding risk.
What this interaction means in plain words
Argatroban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Argatroban belongs to Cardiovascular; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive hemostatic impairment from anticoagulation and serotonergic platelet dysfunction.
What to do
Monitor aPTT and watch for signs of bleeding during argatroban infusion. Adjust argatroban per protocol and reassess the need for the antidepressant if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Argatroban
- Argatroban + Defibrotide Contraindicated
- Argatroban + Ketorolac Contraindicated
- Argatroban + Mifepristone Contraindicated
- Abciximab + Argatroban Major
- Acalabrutinib + Argatroban Major
- Acetylsalicylic acid + Argatroban Major
Frequently asked questions
Can I take Argatroban with Vortioxetine?
MediHelp rates the interaction as moderate. Argatroban and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Argatroban is a direct thrombin inhibitor, and vortioxetine may impair platelet function through reduced platelet serotonin uptake. The combination may increase bleeding risk.
How serious is the interaction between Argatroban and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT and watch for signs of bleeding during argatroban infusion. Adjust argatroban per protocol and reassess the need for the antidepressant if bleeding occurs.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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