Drug interactions
Aripiprazole + Armodafinil
Severity: Minor
Aripiprazole and Armodafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aripiprazole is cleared by CYP3A4 and CYP2D6, so armodafinil's weak CYP3A4 induction may modestly reduce its levels. Their effects on sedation also oppose each other, and armodafinil may worsen agitation in some patients.
What this interaction means in plain words
Aripiprazole and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Armodafinil belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by armodafinil and opposing pharmacodynamic effects on arousal.
What to do
No routine dose change is required. Monitor psychiatric symptoms and aripiprazole efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Armodafinil?
MediHelp rates the interaction as minor. Aripiprazole and Armodafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aripiprazole is cleared by CYP3A4 and CYP2D6, so armodafinil's weak CYP3A4 induction may modestly reduce its levels. Their effects on sedation also oppose each other, and armodafinil may worsen agitation in some patients.
How serious is the interaction between Aripiprazole and Armodafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required. Monitor psychiatric symptoms and aripiprazole efficacy.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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