Drug interactions
Aripiprazole + Ceritinib
Severity: Moderate
Aripiprazole and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise aripiprazole concentrations, increasing adverse effects such as akathisia, sedation and orthostasis. Ceritinib also prolongs QT.
What this interaction means in plain words
Aripiprazole and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Ceritinib belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4, reducing aripiprazole clearance.
What to do
Consider reducing the aripiprazole dose and monitor for adverse effects. Monitor ECG given the QT effects of ceritinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Aripiprazole with Ceritinib?
MediHelp rates the interaction as moderate. Aripiprazole and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise aripiprazole concentrations, increasing adverse effects such as akathisia, sedation and orthostasis. Ceritinib also prolongs QT.
How serious is the interaction between Aripiprazole and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the aripiprazole dose and monitor for adverse effects. Monitor ECG given the QT effects of ceritinib.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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