Drug interactions
Aripiprazole + Chloroquine
Severity: Moderate
Aripiprazole and Chloroquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have some potential to prolong the QTc interval, though aripiprazole's effect is small. Chloroquine inhibits CYP2D6 and may increase aripiprazole concentrations.
What this interaction means in plain words
Aripiprazole and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Chloroquine belongs to Anti Parasitic.
Why it happens
Additive QT effects plus possible CYP2D6 inhibition by chloroquine raising aripiprazole levels.
What to do
Obtain a baseline ECG and monitor QTc, and watch for aripiprazole adverse effects such as akathisia and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Chloroquine?
MediHelp rates the interaction as moderate. Aripiprazole and Chloroquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have some potential to prolong the QTc interval, though aripiprazole's effect is small. Chloroquine inhibits CYP2D6 and may increase aripiprazole concentrations.
How serious is the interaction between Aripiprazole and Chloroquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, and watch for aripiprazole adverse effects such as akathisia and sedation.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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