Drug interactions
Aripiprazole + Dihydroergotamine
Severity: Minor
Aripiprazole and Dihydroergotamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic activity, and a theoretical additive effect with antipsychotics on serotonin toxicity or neuroleptic malignant syndrome has been described. The main clinical concern with dihydroergotamine is its CYP3A4-dependent exposure, but aripiprazole is not a CYP3A4 inhibitor, so the interaction is largely theoretical.
What this interaction means in plain words
Aripiprazole and Dihydroergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and dopaminergic effects; no established pharmacokinetic mechanism.
What to do
No routine change is needed; monitor for agitation, hyperthermia, rigidity, or autonomic instability if the combination is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Aripiprazole with Dihydroergotamine?
MediHelp rates the interaction as minor. Aripiprazole and Dihydroergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dihydroergotamine has serotonergic activity, and a theoretical additive effect with antipsychotics on serotonin toxicity or neuroleptic malignant syndrome has been described. The main clinical concern with dihydroergotamine is its CYP3A4-dependent exposure, but aripiprazole is not a CYP3A4 inhibitor, so the interaction is largely theoretical.
How serious is the interaction between Aripiprazole and Dihydroergotamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for agitation, hyperthermia, rigidity, or autonomic instability if the combination is used.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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