Drug interactions
Aripiprazole + Duloxetine
Severity: Minor
Aripiprazole and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine inhibits CYP2D6 moderately and aripiprazole is cleared by CYP2D6 and CYP3A4, so aripiprazole concentrations may rise modestly. This could increase akathisia, sedation or other dose-related effects.
What this interaction means in plain words
Aripiprazole and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated aripiprazole metabolism by duloxetine.
What to do
Monitor for akathisia, restlessness and sedation after starting duloxetine. Reduce the aripiprazole dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Frequently asked questions
Can I take Aripiprazole with Duloxetine?
MediHelp rates the interaction as minor. Aripiprazole and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duloxetine inhibits CYP2D6 moderately and aripiprazole is cleared by CYP2D6 and CYP3A4, so aripiprazole concentrations may rise modestly. This could increase akathisia, sedation or other dose-related effects.
How serious is the interaction between Aripiprazole and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for akathisia, restlessness and sedation after starting duloxetine. Reduce the aripiprazole dose if adverse effects emerge.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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