Drug interactions
Aripiprazole + Ergotamine
Severity: Minor
Aripiprazole and Ergotamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic or dopaminergic activity, so combined use could in theory contribute to serotonin toxicity or neuroleptic malignant syndrome. Clinical reports of this specific pairing are scarce and the risk is largely predicted.
What this interaction means in plain words
Aripiprazole and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aripiprazole belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic and dopaminergic modulation; no well-established pharmacokinetic or pharmacodynamic mechanism for this pair.
What to do
Counsel the patient to report agitation, fever, tremor, rigidity or diarrhea after starting the combination. Evaluate promptly for serotonin syndrome or neuroleptic malignant syndrome if such symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Aripiprazole with Ergotamine?
MediHelp rates the interaction as minor. Aripiprazole and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have serotonergic or dopaminergic activity, so combined use could in theory contribute to serotonin toxicity or neuroleptic malignant syndrome. Clinical reports of this specific pairing are scarce and the risk is largely predicted.
How serious is the interaction between Aripiprazole and Ergotamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, fever, tremor, rigidity or diarrhea after starting the combination. Evaluate promptly for serotonin syndrome or neuroleptic malignant syndrome if such symptoms appear.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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